Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules
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چکیده
منابع مشابه
Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules
Firm attachments between kinetochores and dynamic spindle microtubules (MTs) are important for accurate chromosome segregation. Centromere protein F (CENP-F) has been shown to include two MT-binding domains, so it may participate in this key mitotic process. Here, we show that the N-terminal MT-binding domain of CENP-F prefers curled oligomers of tubulin relative to MT walls by approximately fi...
متن کاملCENPF (centromere protein F, 350/400ka (mitosin))
DNA/RNA Description The CENPF gene structure consists of twenty exons, ranging from 92 to 3,404 bp, and nineteen introns, ranging from approximately 1 to approximately 10 kb. Transcription 10,294 bp mRNA; 9630 bp open reading frame. Pseudogene No pseudogene. Protein Description The gene encodes a protein associated with the centromere-kinetochore complex, 3210 amino acids (aa), 367594 Da, conta...
متن کاملKEN-dependent degradation of centromere protein F
Introduction Successful completion of chromosome segregation and cytokinesis requires the coordinated activation and inactivation of numerous mitotic regulators. Inactivation is largely brought about by ubiquitindependent proteolysis, with the relevant E3 ubiquitin ligase being the anaphase promoting complex, or cyclosome (APC/C) (Irniger et al., 1995; King et al., 1995; Sudakin et al., 1995). ...
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Microtubules (MTs) are fibrous and tube-like cell substructures exist in cytoplasm of cells which play a vital role in many cellular processes. Surface effects on the vibration of bioliquid MTs surrounded by cytoplasm is investigated in this study. The emphasis is placed on the effect of the motor protein motion on the MTs. The MT is modeled as an orthotropic beam and the surrounded cytoplasm i...
متن کاملLength control of microtubules by depolymerizing motor proteins
In many intracellular processes, the length distribution of microtubules is controlled by depolymerizing motor proteins. Experiments have shown that, following non-specific binding to the surface of a microtubule, depolymerizers are transported to the microtubule tip(s) by diffusion or directed walk and, then, depolymerize the microtubule from the tip(s) after accumulating there. We develop a q...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2015
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201408083